Sesame Care Weight Loss Reviews 2026: Pricing & Verdict

The monthly subscription ($59/month annual, $99/month monthly) covers:

• Video consultations with a board-certified weight loss provider of your choice
• Lab work ordered and reviewed by your provider (availability varies by state)
• Unlimited messaging with your dedicated clinician
• Ongoing clinical oversight including dose adjustments and follow-ups
• Insurance navigation for patients who want brand-name GLP-1 coverage

What it does not include: medication. The prescription itself ships from a pharmacy, and the cost depends on your insurance status and which medication your provider prescribes.

This unbundled model is unusual. Most competitors (Hims, Ro, MEDVi) bundle medication into one monthly price. Sesame separates them, which can be cheaper or more expensive depending on your insurance situation.

1. 1.Sign up and choose a provider. Unlike most telehealth platforms that randomly assign clinicians, Sesame lets you browse providers by specialty, ratings, and price. You pick who you want to see.
2. 2.Complete a video consultation. Same-day appointments are often available. Your provider reviews your medical history, current medications, BMI, and weight loss goals.
3. 3.Lab work (if needed). Your provider may order blood work through Quest Diagnostics or a local lab. Labs are included in the subscription in most states.
4. 4.Prescription and medication. If GLP-1 treatment is clinically appropriate, your provider writes a prescription. For insured patients, Sesame handles prior authorization paperwork. For uninsured patients, medication ships from Costco Pharmacy or another partner pharmacy.

Most patients move from signup to first dose within one week. The provider-choice feature means you can read reviews, check credentials, and select a clinician you trust before the first appointment. That level of control is rare in telehealth.

Sesame offers 14 prescription options, more than any competitor we have reviewed. The full list:

Brand-Name GLP-1 Agonists (require insurance or cash pay at full price): - Wegovy (semaglutide injection) - for weight loss - Ozempic (semaglutide injection) - FDA-approved for type 2 diabetes, prescribed off-label for weight loss - Zepbound (tirzepatide injection) - for weight loss - Mounjaro (tirzepatide injection) - for type 2 diabetes - Rybelsus (oral semaglutide) - for type 2 diabetes

Other Brand-Name Options: - Saxenda (liraglutide) - Victoza (liraglutide) - Trulicity (dulaglutide) - Contrave (bupropion/naltrexone)

Non-GLP-1 Medications: - Metformin - Topiramate - Other adjunctive medications as clinically appropriate

Compounded Options: - Compounded semaglutide (available in all 50 states since October 2024)

This breadth matters. If your insurance covers Wegovy or Zepbound, Sesame's providers handle the prior authorization that can bring your monthly medication cost from $1,000+ down to $25. If you lack insurance, compounded semaglutide at $249 per month through Costco Pharmacy is the fallback. To understand how these medications differ and calculate your dose, use our semaglutide dosage calculator.

Some providers on Sesame charge higher monthly rates. Sesame sets a base price, but individual clinicians can price above it based on their credentials and demand. Always confirm the exact price before your first appointment.

Medication costs depend entirely on your insurance status.

With Insurance (after prior authorization):

Without Insurance (Costco Pharmacy partnership):

Key context: The $25/month figure for insured patients assumes successful prior authorization. Not all insurers cover GLP-1 medications for weight loss, and prior authorization can take days to weeks. Sesame's providers handle the paperwork, but approval is never guaranteed.

For a full breakdown of semaglutide pricing across all platforms, see our guide on how much semaglutide costs.

The annual cost varies dramatically based on your insurance and medication choice.

The insured pathway ($1,008/year) is among the cheapest GLP-1 options in telehealth. The uninsured pathway ($3,696/year for compounded semaglutide) is competitive with MEDVi ($3,767/year) and cheaper than Willow ($3,588+/year). Use our peptide cost calculator to model your specific costs.

Sesame holds an "Excellent" Trustpilot rating. Of the 3,700+ reviews, roughly 83% are four or five stars. The weight loss program accounts for a growing share of reviews since 2024.

What positive reviewers consistently mention: - Transparent pricing with no surprises at checkout - Ability to choose your own provider based on reviews and credentials - Fast appointment scheduling (same-day video visits are common) - Prescriptions sent quickly after consultation - Professional, attentive providers

Representative positive review: "Signed up for the weight loss program, had my video visit the same afternoon, and my Wegovy shipped two days later. My provider walked me through everything and answered my questions via messaging the next day."

What negative reviewers consistently mention: - Confusion about the subscription not including medication cost - Difficulty canceling subscriptions (no self-service cancel button) - Provider quality varies (some clinicians are excellent, others rush through visits) - Billing charged even when providers no-show for appointments - Labs not available in all states despite being advertised as included

Sesame is BBB-accredited with an A- rating and a customer review score of 3.61 out of 5 from 72 reviews. The BBB profile shows a mix of resolved and unresolved complaints, primarily focused on billing and cancellation issues.

The most common BBB complaints:

1. 1.Unauthorized charges after cancellation attempts. Multiple patients report being charged for months after requesting cancellation because the request was not properly processed.
2. 2.Provider no-shows. Several reviews describe booking an appointment, the provider not showing up, and Sesame billing the subscription anyway.
3. 3.Medication pricing confusion. Patients who expected the subscription price to include medication discovered the additional cost after signing up.

Sesame responds to BBB complaints and typically offers resolutions. The A- rating reflects adequate complaint handling, but the pattern of recurring billing issues suggests systemic friction in the cancellation process.

Reddit threads about Sesame Care weight loss reveal a split experience.

Positive patterns on Reddit: - Users praise the speed of getting medication, especially for insured patients who get brand-name GLP-1s approved quickly - The provider-choice feature gets consistent positive mentions - Pricing transparency is frequently cited as a reason for choosing Sesame over competitors

Negative patterns on Reddit: - Isolated reports of incorrect medications being sent - High variability in provider quality (some providers prescribe aggressively, others are conservative) - Frustration with the subscription model for patients who only need periodic check-ins - Reports of providers not reviewing lab work thoroughly before prescribing

The provider variability issue is structural. Sesame is a marketplace, not a medical practice. It connects you with independent providers who set their own clinical standards. That means your experience depends heavily on which provider you choose. Reading provider reviews before booking is essential.

GLP-1 (glucagon-like peptide-1) receptor agonists mimic a hormone your gut produces after eating. They slow gastric emptying, reduce appetite, and improve insulin sensitivity. The result: patients eat less without constant hunger.

Semaglutide (Wegovy, Ozempic) targets the GLP-1 receptor alone. In the STEP 1 trial, patients lost an average of 14.9% of body weight over 68 weeks.

Tirzepatide (Zepbound, Mounjaro) targets both GLP-1 and GIP receptors. The SURMOUNT-5 trial showed tirzepatide produced superior weight loss compared to semaglutide, with average reductions exceeding 20% of body weight.

Both medications require gradual dose escalation over several months to minimize side effects. Your Sesame provider should start you at the lowest dose and increase based on tolerability. For guidance on what to expect week by week, see our guide on how long semaglutide takes to work.

GLP-1 side effects are dose-dependent and affect the majority of patients during the first 4 to 8 weeks. They typically improve as your body adjusts.

Nausea is the most common reason patients discontinue treatment. Slow dose titration, eating smaller meals, and staying hydrated reduce severity. For management strategies, see our guide on how to relieve nausea from semaglutide.

Serious but rare side effects include pancreatitis, gallbladder disease, and potential thyroid tumors (observed in rodent studies). GLP-1 medications are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Disclose your full medical history during your Sesame consultation.

Sesame offers both brand-name and compounded GLP-1 medications. Brand-name versions (Wegovy, Zepbound) are FDA-approved and manufactured under strict quality controls. Compounded versions use the same active ingredients but are prepared by licensed compounding pharmacies and are not FDA-approved products.

The FDA reported 605 adverse events linked to compounded semaglutide and 545 linked to compounded tirzepatide as of July 2025. These include dosing inconsistencies, contamination events, and allergic reactions to inactive ingredients not present in brand-name formulations.

Sesame's compounded semaglutide ships through its Costco Pharmacy partnership. For patients considering compounded options, request a Certificate of Analysis for your medication batch. For a detailed analysis, read our guide on whether compounded tirzepatide is safe.

Prices verified March 2026. Exact costs vary by medication, dosage, and insurance.

Sesame wins if: You have insurance that covers brand-name GLP-1s. The total cost ($59-$99 subscription + $0-$25 medication) is the cheapest pathway to Wegovy or Zepbound. No other platform handles prior authorization as part of its core offering.

Sesame loses if: You are uninsured and want the simplest possible billing. Hims at $199/month with no separate subscription fee is more straightforward, even if the total cost is similar.

For patients weighing tirzepatide specifically, see our guide on where to buy tirzepatide for a broader market overview.

Sesame's strongest competitive advantage is provider choice combined with insurance support. No other platform lets you pick your clinician and then has that clinician handle insurance prior authorization for brand-name medications. For patients with good insurance, this combination saves thousands per year.

Sesame's biggest gap is the lack of structured lifestyle support. Ro includes weekly coaching. Hims offers basic nutrition guidance. Sesame leaves lifestyle changes entirely to the patient-provider relationship, which varies by clinician. If you need structured support alongside medication, Sesame is not the right fit.

There is no self-service cancel button in the Sesame patient portal. Cancellation requires contacting customer support directly. Multiple reviewers on Trustpilot and BBB report being charged for additional months after requesting cancellation because the request was not processed in time.

How to protect yourself: Cancel in writing (email) with at least 72 hours before your next billing cycle. Save the confirmation email. If you signed up for the annual plan, understand that you are committed for 12 months.

Because Sesame is a marketplace connecting patients with independent providers, clinical quality varies. Some providers conduct thorough video consultations with detailed medical history review. Others rush through five-minute appointments and prescribe quickly.

Reddit reports highlight specific concerns: some providers prescribe aggressively without adequate lab review, while others are overly conservative and refuse to prescribe GLP-1s to patients who clearly meet clinical criteria.

How to mitigate this: Use Sesame's provider-choice feature. Read reviews. Check credentials. If your first provider is not a good fit, switch to another one without penalty. This flexibility is Sesame's safety net against inconsistent provider quality.

Sesame does not offer dedicated nutrition coaching, meal planning, or behavioral therapy as part of its weight loss program. Providers give diet and exercise recommendations during consultations, but there is no structured program.

Research consistently shows that GLP-1 medications work best when combined with lifestyle changes. Patients who modify their diet and exercise habits alongside medication lose more weight and maintain it longer. The absence of structured support is a meaningful gap.

For patients who want to understand what dietary changes pair best with GLP-1 therapy, our guide on what to eat on tirzepatide covers evidence-based recommendations. For broader context on which peptides support weight loss, see our best peptides for weight loss guide.

Sesame markets its insurance navigation heavily. The $25/month medication price assumes successful prior authorization. In reality, many insurance plans exclude GLP-1 coverage for weight loss, cover only specific medications, or impose BMI thresholds that not all patients meet.

If your prior authorization is denied, you fall back to the uninsured pricing: $249 per month for compounded semaglutide or $349 per month for brand-name Wegovy through Costco Pharmacy. That price jump from $25 to $249 is significant.

Before signing up: Call your insurance company and ask specifically whether they cover Wegovy or Zepbound for weight management. Ask about prior authorization requirements. This five-minute call prevents the most common source of disappointment with Sesame's pricing promises.